Figure 2.

A, Graph showing Pao₂ to Fio₂ ratio over time in phase 1 estimates with 95% confidence bands based on the linear mixed model (interaction time × intervention; P = .14) for the tissue plasminogen activator (tPA) bolus vs control groups. Asterisks indicate significant (P < .017) differences compared with baseline. Only the tPA bolus group showed significant improvements in Pao₂ to Fio₂ ratio compared with baseline. No significant improvements in Pao₂ to Fio₂ ratio were found in the control group. B, Graph showing the Pao₂ to Fio₂ ratio, which is same as in (A), but further stratifying by requirement of a second tPA bolus at 24 h.