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. 2021 Sep 27;161(3):710–727. doi: 10.1016/j.chest.2021.09.024

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© 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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A, B, Graphs showing D-dimer temporal trends by study group in phase 1 (A) and phase 2 (B). A, In phase 1 (tissue plasminogen activator [tPA] bolus vs control), the intervention significantly changed the temporal trends of the study groups (interaction intervention × time; P < .0001). Asterisks indicate significant (P < .003, adjusted for multiple comparisons by false-discovery rate) differences compared with baseline; only the tPA bolus group showed significant changes in D-Dimer levels compared with baseline. No significant changes in D-Dimer levels were found in the control group. B, In phase 2 (tPA drip vs control), the intervention changed (albeit not significantly at P < .017) the temporal trends of the study groups (interaction intervention × time; P < .013). Asterisks indicate significant (P < .003, adjusted for multiple comparisons by false-discovery rate) differences compared with baseline. Only the tPA drip group showed significant changes in D-dimer levels compared with baseline. No significant changes in D-dimer levels were found in the control group.