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. 2021 Sep 13;9:697100. doi: 10.3389/fped.2021.697100

Table 3.

Neonatal characteristics of infants with or without severe functional disability at 24 months.

Patients with severe functional disability
N = 48
Patients without severe functional disability
N = 454
Missing cases p
Birth weight, median (IQR), g 861.5 (697.5–1,094.5) 1,104 (895–1,360) <0.001
Gestational age, median (IQR), wk 26.9 (25.3–29) 29.5 (27.7–31.3) <0.001
Outborn, n (%) 4 (8.3) 15 (3.3) 0.082
Ethnicity (Not-Hispanic), n (%) 3 (6.3) 15 (3.3) 0.300
Multiple gestation, n (%) 13 (27.1) 159 (35.0) 0.270
Apgar 5th min, median (IQR) 9 (7–9) 9 (8–9) 0.038
Male gender, n (%) 31 (64.6) 220 (48.5) 0.034
Prenatal steroids exposure, n (%) 44 (91.7) 414 (92) 4 0.936
Chorioamnionitis, n (%) 16 (33.3) 83 (18.3) 1 0.013
Sepsis, n (%) 14 (29.2) 40 (8.8) <0.001
Mechanical ventilation, n (%) 33 (68.8) 157 (34.6) <0.001
Periventricular-intraventricular hemorrhage, n (%) 18 (39.1) 55 (12.1) 2 <0.001
Periventricular leukomalacia, n (%) 7 (15.2) 5 (1.1) 2 <0.001
PDA pharmacological treatment, n (%) 20 (41.7) 110 (24.2) 0.009
PDA surgical treatment, n (%) 9 (19.2) 21 (4.8) 15 <0.001
Necrotizing enterocolitis, n (%) 5 (10.4) 13 (2.9) 0.007
ROP surgical treatment, n (%) 8 (16.7) 6 (1.3) <0.001
Human milk feeding at discharge, n (%) 22 (45.8) 320 (70.8) <0.001

PDA, patent ductus arteriosus; ROP, retinopathy of the prematurity.

Missing cases were excluded from the statistical analyses.

The values in bold are statistically significant (p < 0.05).