Table 2.
Association of kidney function indexes with disease progression in COVID-19 patients
| Variables | Univariate Cox regression analysis | Multivariate Cox regression analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Kidney function laboratory parameters (normal value as reference) | ||||
| Hematuria | 2.72 (1.81–4.10) | < 0.001 | 2.38 (1.50–3.78) | < 0.001 |
| Proteinuria | 5.03 (3.34–7.59) | < 0.001 | 2.16 (1.33–3.51) | 0.002 |
| Elevating uric acid | 1.84 (1.09–3.10) | 0.022 | 1.09 (0.83–1.34) | 0.392 |
| Elevating BUN | 7.63 (5.22–11.15) | < 0.001 | 3.54 (2.36–5.31) | < 0.001 |
| Elevating Scr | 5.28 (3.65–7.63) | < 0.001 | 2.84 (1.92–4.21) | < 0.001 |
| Decreasing eGFR | 2.40 (1.73–3.34) | < 0.001 | 1.58 (1.07–2.34) | 0.039 |
| Decreasing Ccr | 2.14 (1.22–3.77) | 0.008 | 1.90 (0.96–3.77) | 0.067 |
Multivariate Cox regression analysis adjusted for age, gender, severe status, heart failure, respiratory failure, total protein, alkaline phosphatase and neutrophil to lymphocyte ratio (NLR). Bold indicates P < 0.05
BUN blood urea nitrogen; Scr Blood creatinine; eGFR estimated glomerular filtration rate; Ccr creatinine clearance rate; AKI acute kidney injury