Recommendation 2

Risk-reducing surgery is recommended to reduce the risk of ovarian cancer in women with a hereditary predisposition or risk. This is endorsed from Jacobson et al. 2018 [23].

Key Evidence for Recommendation 2

We endorse the recommendations from the clinical practice guideline conducted by Jacobson et al. [23] on behalf of the SOGC (The Society of Obstetricians and Gynaecologists of Canada). This guideline scored well on the AGREE II scale. The scores are reported in Table 4–3 in Section 4 of this document. The evidence underpinning the recommendations is comprised of one randomized study and one comparative study.

Justification for Recommendation 2

The Working Group members are confident in their endorsement of this recommendation. The source had adequate quality ratings, there is an excellent alignment with research questions of interest to the Working Group, methods and evidence and synthesis are convincing, and the treatments and patients included in the evidence base are generalizable to the Ontario context.