Recommendation 3

It is premature to recommend acetylsalicylic acid for ovarian cancer prophylaxis in women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2. This is endorsed from Jacobson et al. 2018 [23].

Qualifying Statements for Recommendation 3

• There is an ongoing clinical trial (NCT03480776) determining the effectiveness of the use of acetylsalicylic acid in ovarian cancer.

Key Evidence for Recommendation 3

We endorse the recommendations from the clinical practice guideline conducted by Jacobson et al. [23] on behalf of the SOGC. This guideline scored well on the AGREE II scale. The scores are reported in Table 4–3 in Section 4 of this document. The evidence underpinning the recommendations is comprised of 12 population-based case-control studies.

Justification for Recommendation 3

The Working Group members are confident in their endorsement of this recommendation. The source had adequate quality ratings, there is an excellent alignment with research questions of interest to the Working Group, methods and evidence and synthesis are convincing, and the treatments and patients included in the evidence base are generalizable to the Ontario context.