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. 2021 Sep 26;9:157. doi: 10.1186/s40478-021-01261-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Apoe^−/− mice accumulate more PrP^Sc. a and c Immunoblot analysis of the total PrP protein and that of proteinase K (PK) resistant PrP^Sc in the brain cortex in B6 WT and Apoe^−/− (e^−/−) lines, respectively. Also included are β-actin as the loading control in a and PK digestion control (last lane) in c. b and d Densitometric quantification of total PrP and PrP^Sc protein band optical densities (OD). Values represent mean + SEM from 8 to 10 mice per group. b p < 0.0001 (ANOVA); *p < 0.05, and ****p < 0.0001 (Holm’s-Sidak’s post hoc test). d *p < 0.05 (two-tailed t-test with Welch’s correction)