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. 2021 Sep 26;21:1059. doi: 10.1186/s12885-021-08774-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Reversal of MMP2 stimulation in co-cultures of SaOS-2 and osteoblast by EMMPRIN siRNA transfection. a SaOS-2 and osteoblast showed weak gelatinolytic band for pro-MMP2 when cultured alone (Lanes 1, 2). When osteoblast and SaOS-2 were co-cultured, enhanced stimulation of pro-MMP2 was observed (Lane 3). This stimulation was reversed by transfection of SaOS-2 with EMMPRIN-targeting siRNA (Lanes 4–6). Data shown are representative images of individual cell lines from three separate experiments. b Comparison of grayscale ratio of gelatinolytic band for pro-MMP2 *, p < 0.05 compared with control