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Decrease of VEGF production in co-cultures of SaOS-2 and osteoblast by EMMPRIN siRNA transfection. When osteoblasts and SaOS-2 cells were co-cultured, VEGF expression was increased compared to the SaOS-2-only culture. Transfection of SaOS-2 cells with EMMPRIN-targeting siRNA resulted in a decrease in VEGF expression. * p < 0.05 compared with cells transfected with control siRNA
