Table 2.
Patient Questionnaire
| LDL Cohort (n=4452) | PCSK9 Inhibitor Cohort (n=554) | P Value | |
|---|---|---|---|
| What is your understanding of the main reason you are taking cholesterol medication? | 0.003 | ||
| To prevent a heart attack and/or stroke | 27.3% (1120/4106) | 31.4% (168/535) | |
| To lower cholesterol | 67.0% (2750/4106) | 66.4% (355/535) | |
| To make you feel better | 1.2% (49/4106) | 0.6% (3/535) | |
| Don't know/not sure | 4.6% (187/4106) | 1.7% (9/535) | |
| What do you think is the leading cause of death for men in the United States? | <0.001 | ||
| Heart disease | 61.7% (2536/4113) | 72.6% (389/536) | |
| Cancer | 10.3% (422/4113) | 8.4% (45/536) | |
| Other | 4.3% (178/4113) | 2.4% (13/536) | |
| Don't know/not sure | 23.8% (977/4113) | 16.6% (89/536) | |
| What do you think is the leading cause of death for women in the United States? | <0.001 | ||
| Heart disease | 44.8% (1841/4113) | 58.4% (313/536) | |
| Cancer | 27.7% (1141/4113) | 22.4% (120/536) | |
| Other | 2.4% (100/4113) | 1.7% (9/536) | |
| Don't know/not sure | 25.1% (1031/4113) | 17.5% (94/536) | |
| Can you estimate the chance that you will have a heart attack or stroke within the next 10 y? | 0.263 | ||
| <5% | 12.8% (524/4096) | 10.4% (55/531) | |
| 5% to <10% | 8.5% (348/4096) | 4.9% (26/531) | |
| 10% to <20% | 6.6% (269/4096) | 8.3% (44/531) | |
| 20% to <50% | 8.3% (338/4096) | 8.5% (45/531) | |
| 50% or greater | 9.2% (376/4096) | 13.4% (71/531) | |
| Don't know/not sure | 54.7% (2241/4096) | 54.6% (290/531) | |
| By how much do you think your cholesterol‐lowering medication reduces your risk for having a heart attack or stroke over the next 10 y? | 0.005 | ||
| <5% | 3.3% (136/4108) | 2.4% (13/536) | |
| 5% to <10% | 4.4% (180/4108) | 2.8% (15/536) | |
| 10% to <20% | 6.3% (257/4108) | 3.2% (17/536) | |
| 20% to <50% | 14.4% (592/4108) | 12.5% (67/536) | |
| 50% or greater | 28.2% (1157/4108) | 52.1% (279/536) | |
| Don't know/not sure | 43.5% (1786/4108) | 27.1% (145/536) | |
| What is your LDL? | <0.001 | ||
| <50 mg/dL | 2.1% (85/4115) | 22.6% (121/535) | |
| 50 to <70 mg/dL | 3.3% (135/4115) | 10.8% (58/535) | |
| 70 to <100 mg/dL | 14.1% (581/4115) | 9.2% (49/535) | |
| 100 to <130 mg/dL | 5.8% (237/4115) | 4.1% (22/535) | |
| 130 mg/dL or higher | 3.9% (161/4115) | 5.0% (27/535) | |
| Don't know/not sure | 70.9% (2916/4115) | 48.2% (258/535) | |
| What should your LDL be according to your doctor? | <0.001 | ||
| <50 mg/dL | 3.8% (157/4114) | 11.7% (63/537) | |
| 50 to <70 mg/dL | 7.5% (309/4114) | 13.6% (73/537) | |
| 70 to <100 mg/dL | 13.0% (534/4114) | 16.2% (87/537) | |
| 100 to <130 mg/dL | 3.0% (122/4114) | 3.7% (20/537) | |
| 130 mg/dL or higher | 1.4% (56/4114) | 1.3% (7/537) | |
| Don't know/not sure | 71.4% (2936/4114) | 53.4% (287/537) | |
| Have you ever had any symptoms that you thought were due to taking a statin? | |||
| Any side effects | 29.5% (1201/4070) | 81.7% (428/524) | <0.001 |
| Muscle‐related symptoms | 24.0% (978/4070) | 74.8% (392/524) | <0.001 |
| Memory‐related symptoms | 4.9% (200/4070) | 17.6% (92/524) | <0.001 |
| Abnormal labs (liver, muscle) | 4.1% (166/4070) | 22.5% (118/524) | <0.001 |
| Diabetes mellitus | 0.4% (18/4070) | 1.0% (5/524) | 0.174 |
LDL indicates low‐density lipoprotein; and PCSK9, proprotein convertase subtilisin/kexin type 9.