Table 2.
Rates of Adverse Outcome Events Based on the HDL‐C Categories Overall and in the Absence and Presence of Inflammation
| Variable | Total | HDL‐C Categories | |||
|---|---|---|---|---|---|
| <40 mg/dL | 40–49 mg/dL | 50–59 mg/dL | ≥60 mg/dL | ||
| All | |||||
| No. of participants | 1864 | 514 | 537 | 407 | 406 |
| Person‐years | 8888.3 | 2323.6 | 2549.8 | 1922.2 | 2092.7 |
| eMACE* | |||||
| Events, n (%) | 140 (7.5) | 44 (8.6) | 44 (8.2) | 31 (7.6) | 21 (5.2) |
| Incidence rate per 1000 person‐years | 15.8 | 18.9 | 17.3 | 16.1 | 10.0 |
| Non‐fatal MACE | |||||
| Events, n (%) | 122 (6.5) | 39 (7.6) | 37 (6.9) | 28 (6.9) | 18 (4.4) |
| Incidence rate per 1000 person‐years | 13.7 | 16.8 | 14.5 | 14.6 | 8.6 |
| All‐cause mortality | |||||
| Events, n (%) | 96 (5.2) | 37 (7.2) | 25 (4.7) | 19 (4.7) | 15 (3.7) |
| Incidence rate per 1000 person‐years | 10.4 | 15.1 | 9.5 | 9.5 | 7.0 |
| In the absence of inflammation | |||||
| No. of participants | 1142 | 260 | 314 | 267 | 301 |
| Person‐years | 5495.5 | 1141.9 | 1473.1 | 1291.2 | 1589.4 |
| eMACE | |||||
| Events, n (%) | 76 (6.7) | 24 (9.2) | 25 (8.0) | 18 (6.7) | 9 (3.0) |
| Incidence rate per 1000 person‐years | 13.8 | 21.0 | 17.0 | 13.9 | 5.7 |
| Non‐fatal MACE | |||||
| Events, n (%) | 67 (5.9) | 21 (8.1) | 22 (7.0) | 16 (6.0) | 8 (2.7) |
| Incidence rate per 1000 person‐years | 12.2 | 18.4 | 14.9 | 12.4 | 5.0 |
| All‐cause mortality | |||||
| Events, n (%) | 45 (3.9) | 18 (6.9) | 11 (3.5) | 9 (3.4) | 7 (2.3) |
| Incidence rate per 1000 person‐years | 7.9 | 14.9 | 7.3 | 6.7 | 4.3 |
| In the presence of inflammation | |||||
| No. of participants | 722 | 254 | 223 | 140 | 105 |
| Person‐years | 3392.8 | 1181.7 | 1076.7 | 631.0 | 503.3 |
| eMACE | |||||
| Events, n (%) | 64 (8.9) | 20 (7.9) | 19 (8.5) | 13 (9.3) | 12 (11.4) |
| Incidence rate per 1000 person‐years | 18.9 | 16.9 | 17.6 | 20.6 | 23.8 |
| Non‐fatal MACE | |||||
| Events, n (%) | 55 (7.6) | 18 (7.1) | 15 (6.7) | 12 (8.6) | 10 (9.5) |
| Incidence rate per 1000 person‐years | 16.2 | 15.2 | 13.9 | 19.0 | 19.9 |
| All‐cause mortality | |||||
| Events, n (%) | 51 (7.1) | 19 (7.5) | 14 (6.3) | 10 (7.1) | 8 (7.6) |
| Incidence rate per 1000 person‐years | 14.3 | 15.2 | 12.6 | 15.1 | 14.8 |
eMACE indicates extended major adverse cardiovascular events; and HDL‐C, high‐density lipoprotein cholesterol.
*
eMACE included both fatal and non‐fatal major cardiovascular events, such as myocardial infarction, unstable angina, coronary intervention/surgery, hospitalization for heart failure, symptomatic arrhythmia, and/or cardiac death.