Table 1.
Patient Demographics
| All Patients With Implantation (n=68) | Withdrawn at the End of Run‐in Because of BP Criterion (n=21) | All Randomized Following Run‐in (n=47) | P (Withdrawn vs Randomized) | Control (n=21) | Treatment (n=26) | P (Control vs Treatment) | |
|---|---|---|---|---|---|---|---|
| Age, y | 74.2±8.3 | 74.7±7.5 | 74.0±8.7 | 0.755 | 74.9±8.5 | 73.2±9.0 | 0.518 |
| Men | 39 (57.4) | 9 (42.9) | 30 (63.8) | 0.121 | 15 (71.4) | 15 (57.7) | 0.375 |
| Height, cm | 167.9±8.6 | 165.7±8.2 | 168.8±8.7 | 0.17 | 168.0±7.1 | 169.5±10.0 | 0.587 |
| Weight, kg | 85.8±15.1 | 82.6±10.6 | 87.1±16.7 | 0.258 | 88.5±16.0 | 86.1±17.5 | 0.630 |
| LV ejection fraction, % | 59.6±5.8 | 60.4±6.0 | 59.2±5.7 | 0.46 | 58.4±4.9 | 59.8±6.3 | 0.414 |
| Medical history | |||||||
| Diabetes mellitus | 29 (42.6) | 8 (38.1) | 21 (44.7) | 0.791 | 9 (42.9) | 12 (46.2) | 0.999 |
| Prior atrial fibrillation | 17 (25.0) | 6 (28.6) | 11 (23.4) | 0.764 | 6 (28.6) | 5 (19.2) | 0.505 |
| Coronary artery disease | 23 (33.8) | 4 (19) | 19 (40.4) | 0.103 | 9 (42.9) | 10 (38.5) | 0.775 |
| Stroke | 2 (2.9) | 1 ( 4.8) | 1 (2.1) | 0.526 | 0 (0) | 1 (3.8) | 0.999 |
| Pacemaker | |||||||
| New implant | 46 (67.6) | 16 (76.2) | 30 (63.8) | 0.405 | 15 (71.4) | 15 (57.7) | 0.375 |
| Replacement | 22 (32.4) | 5 (23.8) | 17 (36.2) | 6 (28.6) | 11 (42.3) | ||
| Indication | |||||||
| Sick sinus syndrome | 23 (33.8) | 7 (33.3) | 16 (34.0) | 0.999 | 9 (42.9) | 7 (26.9) | 0.355 |
| Bradycardia | 13 (19.1) | 4 (19.0) | 9 (19.1) | 0.999 | 5 (23.8) | 4 (15.4) | 0.486 |
| Atrioventricular block I | 10 (14.7) | 2 (9.5) | 8 (17.0) | 0.712 | 4 (19.0) | 4 (15.4) | 0.999 |
| Atrioventricular block II | 20 (29.4) | 4 (19.0) | 16 (34.0) | 0.259 | 5 (23.8) | 11 (42.3) | 0.227 |
| Atrioventricular block III | 7 (10.3) | 3 (14.3) | 4 (8.5) | 0.668 | 1 (4.8) | 3 (11.5) | 0.617 |
| Other | 2 (2.9) | 0 (0) | 2 (4.3) | 0.999 | 1 (4.8) | 1 (3.8) | 0.999 |
| Medications, n | 3.4±1.7 | 3.5±2.1 | 3.3±1.5 | 0.691 | 3.3±1.4 | 3.3±1.6 | 0.886 |
| Medication use | |||||||
| Loop diuretic | 49 (72.1) | 19 (90.5) | 30 (63.8) | 0.039 | 14 (66.7) | 16 (61.5) | 0.768 |
| Potassium‐sparing diuretic | 5 (7.4) | 1 (4.8) | 4 (8.5) | 0.955 | 2 (9.5) | 2 (7.7) | 0.999 |
| ß‐Blocker | 24 (35.3) | 5 (23.8) | 19 (40.4) | 0.273 | 6 (28.6) | 13 (50) | 0.232 |
| ACEI | 37 (54.4) | 8 (38.1) | 29 (61.7) | 0.113 | 15 (71.4) | 14 (53.8) | 0.245 |
| ARB | 29 (42.6) | 12 (57.1) | 17 (36.2) | 0.121 | 6 (28.6) | 11 (42.3) | 0.375 |
| CCB | 46 (67.6) | 15 (71.4) | 31 (66.0) | 0.782 | 14 (66.7) | 17 (65.4) | 0.999 |
| α‐Agonist | 14 (20.6) | 6 (28.6) | 8 (17.0) | 0.336 | 5 (23.8) | 3 (11.5) | 0.437 |
| Centrally acting agent | 6 (8.8) | 1 (4.8) | 5 (10.6) | 0.658 | 3 (14.3) | 2 (7.7) | 0.644 |
Values are mean±SD or number (percentage). ACEI indicates angiotensin‐converting enzyme inhibitor; ARB, aldosterone receptor blocker; BP, blood pressure; CCB, calcium channel blocker; and LV, left ventricular.