Table 5.
Competing Risk Regression Analysis by Postevent Mean LDL‐C, Stratified by Presence or Absence of Significant Large‐Artery Atherosclerosis
| Postevent mean LDL‐C | No. of events/No. of patients | Unadjusted SHR (95% CI) | SHR (95% CI) adjusted for age and sex | SHR (95% CI) adjusted for age, sex, and vascular risk factors* | P for interaction | |
|---|---|---|---|---|---|---|
| <1.80 mmol/L | ≥1.80 mmol/L | <1.80 mmol/L | <1.80 mmol/L | <1.80 mmol/L | ||
| All recurrent stroke | ||||||
| LAD+ | 13/142 | 56/340 | 0.54 (0.30–0.99)† | 0.55 (0.30–1.02) | 0.42 (0.21–0.83)† | 0.006 |
| LAD− | 16/137 | 54/285 | 0.63 (0.36–1.09) | 0.59 (0.33–1.03) | 0.53 (0.28–0.99)† | |
| Recurrent ischemic stroke | ||||||
| LAD+ | 12/144 | 44/338 | 0.64 (0.34–1.21) | 0.65 (0.34–1.24) | 0.52 (0.24–1.09) | 0.043 |
| LAD− | 14/137 | 42/285 | 0.73 (0.40–1.33) | 0.68 (0.37–1.26) | 0.57 (0.28–1.16) | |
| Intracerebral hemorrhage | ||||||
| LAD+ | 1/148 | 12/334 | 0.18 (0.02–1.41) | 0.19 (0.03–1.41) | 0.14 (0.02–0.90)† | 0.14 |
| LAD− | 2/136 | 12/286 | 0.35 (0.08–1.56) | 0.34 (0.08–1.45) | 0.43 (0.10–1.81) | |
| Major adverse cardiovascular event | ||||||
| LAD+ | 32/138 | 106/344 | 0.72 (0.49–1.07) | 0.73 (0.49–1.07) | 0.65 (0.42–0.99)† | 0.005 |
| LAD− | 24/132 | 84/290 | 0.62 (0.40–0.98)† | 0.57 (0.36–0.90)† | 0.53 (0.32–0.88)† | |
Postevent mean LDL‐C ≥1.80 mmol/L as the reference group. LAD+ indicates with significant large‐artery atherosclerosis; LAD−, without significant large‐artery atherosclerosis; LDL‐C, low‐density lipoprotein cholesterol; and SHR, subdistribution hazard ratio.
*
Diabetes mellitus, atrial fibrillation, history of ischemic heart disease, history of transient ischemic attack or stroke, glomerular filtration rate, and postevent mean systolic blood pressure.
†
P<0.05.