. 2021 Aug 7;10(16):e021855. doi: 10.1161/JAHA.121.021855

Table 6.

Competing Risk Regression Analysis by Postevent Mean LDL‐C, Stratified by Ischemic Stroke Subtypes

Postevent mean LDL‐C	No. of events/No. of patients		Unadjusted SHR (95% CI)	SHR (95% CI) adjusted for age and sex	SHR (95% CI) adjusted for age, sex, and vascular risk factors^*	P for interaction
Postevent mean LDL‐C	<1.80 (mmol/L)	≥1.80 (mmol/L)	<1.80 (mmol/L)	<1.80 (mmol/L)	<1.80 (mmol/L)	P for interaction
All recurrent stroke
Large‐artery atherosclerosis	8/95	40/222	0.46 (0.21–0.97)^†	0.44 (0.21–0.94)^†	0.37 (0.14–0.99)^†	0.006
Other ischemic stroke subtypes	21/184	70/403	0.67 (0.41–1.08)	0.64 (0.39–1.04)	0.52 (0.31–0.89)^†	0.006
Recurrent ischemic stroke
Large‐artery atherosclerosis	8/96	34/221	0.54 (0.25–1.16)	0.52 (0.24–1.11)	0.44 (0.17–1.14)	0.042
Other ischemic stroke subtypes	18/185	52/402	0.78 (0.46–1.34)	0.75 (0.44–1.29)	0.58 (0.32–1.06)	0.042
Intracerebral hemorrhage
Large‐artery atherosclerosis	0/98	6/219	…	…	…	0.090
Other ischemic stroke subtypes	3/186	18/401	0.36 (0.11–1.22)	0.37 (0.11–1.23)	0.36 (0.10–1.29)	0.090
Major adverse cardiovascular event
Large‐artery atherosclerosis	18/90	79/227	0.53 (0.32–0.87)	0.49 (0.30–0.81)^‡	0.48 (0.28–0.84)^†	0.005
Other ischemic stroke subtypes	38/180	111/407	0.78 (0.54–1.13)	0.75 (0.52–1.09)	0.64 (0.43–0.95)^†	0.005

Postevent mean LDL‐C ≥1.80 mmol/L as the reference group. LDL‐C indicates low‐density lipoprotein cholesterol; and SHR, subdistribution hazard ratio.

Diabetes mellitus, atrial fibrillation, history of ischemic heart disease, history of transient ischemic attack or stroke, glomerular filtration rate, and postevent mean systolic blood pressure.

^{^†}

P<0.05.

^{^‡}

P<0.01.