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. 2021 Aug 7;10(16):e019948. doi: 10.1161/JAHA.120.019948

Figure 7. Cell proliferation and differentiation pathways genes are prioritized targets in the aging heart in association with reactive oxygen species (ROS).

Figure 7

A, Merged networks from human ROS data in aged hearts show prioritized nodes with high betweenness centrality (MYC, AKT, ERK1/2, ERK, FOXO3, P38 MAPK, NFKB [complex], and PI3K [complex]) and high closeness centrality (MYC, AKT, NFKB [complex], P38 MAPK, PI3K [complex], ERK1/2, RNF4, and ERK). B, Rat merged networks identified prioritized nodes with high betweenness centrality (TP53, MYC, adenosine triphosphate, JNK, ERK, NFKB [complex], AKT, and ERK1/2) and high closeness centrality (TP53, MYC, adenosine triphosphate, immunoglobulin, SOD1, mitochondrial complex I, ERK, and AKT).