Table 6.

Minimum number of patients needed in each cohort and overall, assuming a 95% confidence level and 5% margin of error for the percentage of cases changed

Cohort	Expected percentage of cases changed	Number of patients needed in cohort	Percentage of overall sample in cohort	Total sample size needed
Stage II patients	34*	345	45	767
Stage III patients	46*	382	55	695
Patients with (−) ctDNA result	25	289	77.25	375

*Based on the highest percentage of cases changed within each stage from table 4.

ctDNA, circulating tumour DNA.