Table 1.

Results of mendelian randomization between genetically predicted thyrotropin (exposure) and body mass index (outcome)

Analysis type		NSNV	β	SE	P	Q	Q_P	Egger intercept	Intercept_P
IVW, fixed	Model 1	65	.011	0.005	.011	127.351	4.292 × 10–6	0.001	.231
	Model 2	48	.008	0.005	.144	79.911	.002	3.859 × 10–4	.675
IVW, random	Model 1	65	.011	0.006	.073	127.351	4.292 × 10–6	0.001	.231
	Model 2	48	.008	0.007	.263	79.911	.002	3.859 × 10–4	.675
MR-Egger	Model 1	65	–.005	0.015	.727	124.456	6.377 × 10–6	0.001	.231
	Model 2	48	.001	0.016	.935	79.602	.002	3.859 × 10–4	.675

Model 1, crude; Model 2, SNVs associated with confounding factors (blood pressure, blood lipids, or blood glucose) were all excluded by the phenome-wide association study. Q and Q_P represent the Cochran Q value and corresponding P value for estimated heterogeneity; Egger intercept and intercept_P represent estimated pleiotropy effect and corresponding P value.

Abbreviations: IVW, inverse variant-weighted; MR, mendelian randomization; SNV, single-nucleotide variation (formerly single-nucleotide polymorphism [SNP]).