Table 2.
Results of mendelian randomization between genetically predicted thyrotropin (exposure) and obesity (outcome)
| Analysis type | NSNV | OR (95%CI) | P | Q | Q_P | Egger intercept | Intercept_P | |
|---|---|---|---|---|---|---|---|---|
| IVW, fixed | Model 1 | 60 | 1.162 (0.997-1.354) | .055 | 75.737 | .070 | 0.013 | .208 |
| Model 2 | 40 | 1.037 (0.872-1.232) | .682 | 45.395 | .223 | –0.009 | .478 | |
| IVW, random | Model 1 | 60 | 1.162 (0.988-1.336) | .090 | 75.737 | .070 | 0.013 | .208 |
| Model 2 | 40 | 1.037 (0.850-1.224) | .704 | 45.395 | .223 | –0.009 | 0.478 | |
| MR-Egger | Model 1 | 60 | 0.920 (0.520-1.319) | .683 | 73.678 | .080 | 0.013 | .208 |
| Model 2 | 40 | 1.190 (0.769-1.611) | .423 | 44.790 | .208 | –0.009 | .478 |
Model 1, crude; Model 2, SNVs associated with confounding factors (blood pressure, blood lipids, or blood glucose) were all excluded by the phenome-wide association study. Q and Q_P represent the Cochran Q value and corresponding P value for estimated heterogeneity; Egger intercept and intercept_P represent estimated pleiotropy effect and corresponding P value.
Abbreviations: IVW, inverse variant weighted; MR, mendelian randomization; OR, odds ratio; SNV, single-nucleotide variations (formerly single-nucleotide polymorphisms [SNPs]).