Table 3.
Results of mendelian randomization between genetically predicted body mass index (exposure) and thyrotropin (outcome)
| Analysis type | NSNV | β | SE | P | Q | Q_P | Egger intercept | Intercept_P | |
|---|---|---|---|---|---|---|---|---|---|
| IVW, fixed | Model 1 | 918 | .031 | 0.012 | .010 | 1111.565 | 9.689 × 10–6 | 7.863 × 10–4 | .191 |
| Model 2 | 903 | .038 | 0.012 | .002 | 1079.502 | 3.938 × 10–5 | 4.062 × 10–4 | .519 | |
| IVW, random | Model 1 | 918 | .031 | 0.013 | .020 | 1111.565 | 9.689 × 10–6 | 7.863 × 10–4 | .191 |
| Model 2 | 903 | .038 | 0.013 | .004 | 1079.502 | 3.938 × 10–5 | 4.062 × 10–4 | .519 | |
| MR-Egger | Model 1 | 918 | –.021 | 0.042 | .612 | 1109.488 | 1.060 × 10–5 | 7.863 × 10–4 | .191 |
| Model 2 | 903 | .011 | 0.045 | .807 | 1079.004 | 3.738 × 10–5 | 4.062 × 10–4 | .519 |
Model 1, crude; Model 2, SNVs associated with confounding factors (thyroid antibodies, thyroxine, or triiodothyronine) were all excluded by the phenome-wide association study. Q and Q_P represent the Cochran Q value and corresponding P value for estimated heterogeneity; Egger intercept and intercept_P represent estimated pleiotropy effect and corresponding P value.
Abbreviations: IVW, inverse variant weighted; MR, mendelian randomization; SNV, single-nucleotide variations (formerly single-nucleotide polymorphisms [SNPs]).