Table 4.
Results of mendelian randomization between genetically predicted obesity (exposure) and thyrotropin (outcome)
| Analysis type | NSNV | β | SE | P | Q | Q_P | Egger intercept | Intercept_P | |
|---|---|---|---|---|---|---|---|---|---|
| IVW, fixed | Model 1 | 5 | –.008 | 0.012 | .514 | 5.284 | .259 | 9.178 × 10–4 | .970 |
| Model 2 | 4 | .003 | 0.009 | .731 | 1.462 | .481 | –0.002 | .922 | |
| IVW, random | Model 1 | 5 | –.008 | 0.013 | .570 | 5.284 | .259 | 9.178 × 10–4 | .970 |
| Model 2 | 4 | .003 | 0.013 | .809 | 1.462 | .481 | –0.002 | .922 | |
| MR-Egger | Model 1 | 5 | –.012 | 0.117 | .923 | 5.281 | .152 | 9.178 × 10–4 | .970 |
| Model 2 | 4 | .013 | 0.089 | .899 | 1.474 | .688 | –0.002 | .922 |
Model 1, crude; Model 2, rs571312 associated with confounding factor (thyroxine level) was excluded by the phenome-wide association study. Q and Q_P represent the Cochran Q value and corresponding P value for estimated heterogeneity; Egger intercept and intercept_P represent estimated pleiotropy effect and corresponding P value.
Abbreviations: IVW, inverse variant weighted; MR, mendelian randomization; SNV, single-nucleotide variations (formerly single-nucleotide polymorphisms [SNPs]).