Table 5.
Results of mendelian randomization between genetically predicted body mass index (exposure) and free 3,5,3′-triiodothyronine, together with free thyroxine (outcome)
| Analysis type | NSNV | β | SE | P | Q | Q_P | Egger intercept | Intercept_P | |
|---|---|---|---|---|---|---|---|---|---|
| IVW, fixed | fT3 | 2 | 10.123 | 2.523 | < .001 | 2.299 | .129 | – | – |
| fT4 | 4 | –1.237 | 1.633 | .449 | 36.704 | 5.314 × 10–8 | 0.248 | .516 | |
| IVW, random | fT3 | 2 | 10.123 | 3.826 | .008 | 2.299 | 0.129 | – | – |
| fT4 | 4 | –1.237 | 5.712 | .829 | 36.704 | 5.314 × 10–8 | 0.248 | .516 | |
| MR-Egger | fT3 | 2 | – | – | – | – | – | – | – |
| fT4 | 4 | –19.254 | 23.834 | .504 | 36.704 | 5.314 × 10–8 | 0.248 | .516 |
Q and Q_P represent the Cochran Q value and corresponding P value for estimated heterogeneity; Egger intercept and intercept_P represent estimated pleiotropy effect and corresponding P value.
Abbreviations: fT3, free 3,5,3′-triiodothyronine; fT4, free thyroxine; IVW, inverse variant weighted; MR, mendelian randomization; SNV, single-nucleotide variation (formerly single-nucleotide polymorphism [SNP]).