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The link between IGF2BP2 and T2DM. Overexpression of IGF2BP2 can disrupt the development of the pancreas, destroy the repair of β cells, and also contribute to obesity and T2DM by inhibiting the expression of UCP1 and promoting the translation of IGF-2. IGF2BP2, insulin-like growth factor 2 (IGF-2) messenger RNA-binding protein 2; T2DM, type 2 diabetes mellitus; UCP1, uncoupling protein 1 (also known as thermogenin).
