Table 1.
Clinical and demographic characteristics of study participants
| APA | BPA | P values | |
|---|---|---|---|
| N | 40 | 40 | |
| Age (yrs) | 51 [43, 64] | 50 [40, 63] | 0.72 |
| Men (n, %) | 22 (55.0%) | 18 (45.0%) | 0.37 |
| BMI (kg/m2) | 24.3 [22.5, 26.6] | 24.1 [22.3, 26.2] | 0.81 |
| Systolic BP (mmHg) | 138 [126, 150] | 137 [126, 147] | 0.54 |
| Diastolic BP (mmHg) | 86 [76, 97] | 89 [82, 100] | 0.19 |
| Number of AHTs (n) | 2.0 [1.0, 2.0] | 1.0 [1.0, 2.0] | 0.18 |
| Serum potassium (mM) | 3.9 [3.5, 4.2] | 4.1 [4.0, 4.3] | 0.001 |
| Potassium replacement (n, %) | 36 (90.0%) | 23 (57.5%) | 0.001 |
| eGFR (mL/min/1.73 m2) | 83 [68, 88] | 80 [73, 93] | 0.90 |
| PAC (ng/dL) | 39.2 [27.6, 58.8] | 24.3 [17.3, 28.5] | <0.0001 |
| PRA (ng/mL/h) | 0.30 [0.20, 0.30] | 0.30 [0.20, 0.45] | 0.80 |
| ARR (ng/dL per ng/mL/h) | 134.6 [82.0, 208.8] | 86.8 [48.6, 116.3] | 0.0006 |
| Urinary aldosterone (μg/day) | 26.3 [17.8, 33.8] | 13.0 [9.4, 14.8] | <0.0001 |
| Cortisol after DST (μg/dL) | 0.80 [0.65, 1.10] | 0.70 [0.55, 0.90] | 0.09 |
| Lateralization index | 9.3 [5.3, 21.8] | 1.3 [1.2, 1.9] | <0.0001 |
| Contralateral suppression (n, %) | 37 (92.5%) | NA | NA |
All variables are shown as median [interquartile range] or number (percentage). Differences between APA and BPA were assessed by the Mann-Whitney U test for continuous variables and Fisher or Chi-squared test for categorical variables.
Abbreviations: AHT, antihypertensive agents; APA, aldosterone-producing adenoma; ARR, aldosterone-to-renin ratio; AVS, adrenal venous sampling; BMI, body mass index; BP, blood pressure; BPA, bilateral primary aldosteronism; DST, 1 mg dexamethasone suppression test; eGFR, estimated glomerular filtration ratio; NA, not applicable; PAC, plasma aldosterone concentration; PRA, plasma renin activity.