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. 2021 Jun 7;106(10):3007–3018. doi: 10.1210/clinem/dgab407

Figure 1.

Figure 1.

A and B, effects of diagnosis on stimulated cortisol (CORT); and C and D, adrenocorticotropin (ACTH) during dexamethasone (DEX)-suppressed corticotropin-releasing hormone (CRH)-stimulation tests in women with perimenopausal depression (n = 20) and control women (n = 20). No significant differences were observed between women with perimenopausal depression (PMD) and control women in the individual time points in cortisol (effect of diagnosis: P = .94, effect of time: P < .001, diagnosis by time interaction: P = .82) and ACTH (effect of diagnosis: P = .72, effect of time; P < .001, diagnosis by time interaction: P = .05) after CRH administration (A and C, respectively). Similarly, areas under the curve (AUCs) of cortisol (P = .94) and ACTH (P = .87) after CRH administration were not significantly different (B and D, respectively). Values for cortisol are square root–transformed and those for ACTH are log-transformed. Values in A and B are least squares means ± 95% CI; values in C and D are median and interquartile range. For the repeated measures (baseline average to 75 minutes), linear mixed models were used on the square root–transformed CORT and log-transformed ACTH; the P values were obtained for each time point in the model. For all other variables, the Wilcoxon rank sum test was used.