Figure 2.

Study flow chart. Twenty-seven patients with generalized or partial lipodystrophy were enrolled in the study. Of the 17 patients who initiated metreleptin (initiation), 1 did not complete the study procedures for the short-term study (period 2) but was continued on metreleptin and re-evaluated at 6 months, and 1 completed the short-term study but was excluded from analysis of the 6-month data because of noncompliance with metreleptin. Eight patients who were taken off metreleptin for a 2-week period (withdrawal) completed the study and were analyzed.