Figure 4.

Effects of metreleptin initiation or withdrawal on catecholamines in patients with lipodystrophy. (A) Dopamine and (B) epinephrine did not change from baseline to 2 weeks (2w; gray circles) or 6 months (6mo; blue circles) after metreleptin initiation or 2 weeks after metreleptin withdrawal (2w; gray squares). (C) Norepinephrine did not change from baseline to 2 weeks or 6 months after metreleptin initiation but decreased 2 weeks following metreleptin withdrawal. Patients with generalized lipodystrophy are shown as circles or squares without borders and those with partial lipodystrophy as circles with black borders. Comparisons were made using Wilcoxon rank-signed test and paired t-test for nonnormally and normally distributed data, respectively. Linear mixed effects models applying a Dunnett correction for multiple comparisons were used for outcomes measured at >2 time points. P < 0.05 represented statistical significance. P-values are 2-sided.