Figure 5.

Effects of metreleptin initiation or withdrawal on thyroid hormones in patients with lipodystrophy. (A) Thyroid stimulating hormone (TSH) did not change from baseline to 2 weeks (2w; gray circles) or 6 months (6mo; blue circles) after metreleptin administration or after 2 weeks (2w; gray squares) of metreleptin withdrawal. (B) Free thyroxine (T4) did not change from baseline to 2 weeks or 6 months after metreleptin administration but decreased after 2 weeks of metreleptin withdrawal. (C) Total triiodothyronine (T3) did not change at any time point from baseline following metreleptin initiation or withdrawal. (D) Free triiodothyronine (T3) increased from baseline to 2 weeks and 6 months after metreleptin initiation and decreased 2 weeks after metreleptin withdrawal. Patients with generalized lipodystrophy are shown as circles or squares without borders and those with partial lipodystrophy as circles with black borders. Comparisons were made using Wilcoxon rank-signed test and paired t-test for nonnormally and normally distributed data, respectively. Linear mixed effects models applying a Dunnett correction for multiple comparisons were used for outcomes measured at >2 time points. P < 0.05 represented statistical significance. P-values are 2-sided.