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. 2021 Sep 24;114(5):544–553. doi: 10.1007/s12185-021-03215-6

Fig. 1.

Fig. 1

Cell surface interactions of bi-specific CMV-CD19CAR T cells. CMV cytomegalovirus, TCR T cell receptor complex, CAR chimeric antigen receptor, Truncated EGF epidermal growth factor. Bi-specific T cells will be produced by first selecting CMVpp65-specific T cells from leukapheresis products based on interferon-γ-positivity, and then transducing them with a lentivirus encoding a CAR specific for the CD19 antigen. In addition to the CD19 CAR, our lentivirus construct encodes a truncated EGF receptor (EGFRt) that is recognized by the antibody cetuximab for the purpose of T cell tracking and potentially T cell ablation