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Arabidopsis models of RNA-directed DNA methylation (RdDM): double-stranded RNAs (dsRNAs) proceed into small-interfering RNAs (siRNAs) via canonical and non-canonical pathways. Both pathways undergo two steps: (A) in the first step, siRNAs are produced, which subsequently bind with argonaut (AGO) and (B) in the second step, DNA methylation leads to chromatin remodeling resulting in gene silencing via transcriptional gene silencing (TGS).
