FIG 2.

Screening of EBV proteins for modulators of type I and type II IFN signaling. Individual plasmid constructs expressing EBV proteins were transfected into HEK293 cells, along with pISRE-Luc (A) or pGAS-Luc (B) plus pSV-Rluc as an internal control. The ISRE and GAS promoters were induced by treatment with 1,000 U/ml of IFN-β and 50 ng/ml of IFN-γ, respectively, for 24 h. The relative luciferase activity is represented as the fold activation. The mock group transfected with an empty vector is highlighted in red, which was used as a reference to determine the activation or suppression of the two reporters. The BGLF2 group is indicated in green.