TABLE 1.
Native and codon-modified sequences encoding the C-terminal region of the nsP4 protein of nine alphaviruses
| Virus | Native or modified | Sequence |
|---|---|---|
| SFV | Native | GAGGTAGAGGGCTGCAAAAGTATCCTCATAGCCATGGCCACCTTGGCGAGGGACATTAAGGCGTTTAAGAAATTGAGAGGACCTGTTATACACCTCTACGGCGGTCCTAGATTGGTGCGT |
| Modified | GAGGTgGAaGGCTGCAAgAGcATCCTgATcGCCATGGCCACacTGGCcAGaGACATcAAGGCcTTcAAGAAAcTGAGAGGcCCcGTgATcCACCTgTACGGCGGaCCTAGAcTcGTGCGg | |
| CHIKV | Native | TCTAGGTACGAAGTGCAGGGTATATCAGTTGTGGTAATGTCCATGGCCACCTTTGCAAGCTCCAGATCCAACTTCGAGAAGCTCAGAGGACCCGTCATAACTTTGTACGGCGGTCCTAAA |
| Modified | TCTAGaTACGAgGTGCAGGGcATcagcGTgGTGGTcATGagCATGGCCACCTTcGCcAGCagCAGAagCAACTTCGAGAAGCTgAGAGGcCCCGTgATcACccTGTAtGGCGGaCCTAAA | |
| ONNV | Native | TCAAGGTATGAAGTACAAGGAATAACAGCCGTAATAACATCAATGGCTACCTTTGCGAGTAGCAAAGAAAACTTTAAAAAACTAAGAGGGCCCGTCGTAACCTTGTACGGCGGACCTAAA |
| Modified | TCAAGaTAcGAgGTgCAgGGcATcACcGCCGTgATcACcagcATGGCcACaTTcGCcAGcAGCAAAGAgAACTTcAAgAAACTgAGAGGcCCCGTCGTgACCcTGTAtGGCGGACCTAAA | |
| RRV | Native | TCTCGGTATGAGGTGAACGGGACCGGCAACATAGTGCGAGCAATGGCCACACTGGCCAAGAGCCTGAAGAATTTTAAAAAGCTGCGTGGACCCATCGTACACCTCTACGGCGGTCCTAAA |
| Modified | TCTCGcTAcGAaGTGAACGGcACCGGCAACATcGTcaGAGCcATGGCCACACTGGCCAAGAGCCTGAAGAAcTTcAAgAAGCTGaGaGGcCCCATCGTgCACCTgTAtGGCGGaCCTAAA | |
| MAYV | Native | ACCAGATACGAGGTGGAAGGGGGTTACAACCTATTGTTGGCTATGTCCACCTTTGCACACAGTATGAAGAATTTTTCTGCATTGAGGGGACCCGTCATACACTTGTACGGCGGTCCTAAA |
| Modified | ACCcGcTAtGAGGTGGAAGGcGGcTACAAtCTgcTGcTGGCcATGagCACaTTcGCcCACAGcATGAAGAAcTTcagcGCccTGAGaGGcCCCGTgATcCAtcTttAtGGCGGcCCTAAg | |
| SINV | Native | ACCCGGTATGAGGTAGACAATATTACACCTGTCCTACTGGCATTGAGAACTTTTGCCCAGAGCAAAAGAGCATTCCAAGCCATCAGAGGGGAAATAAAGCATCTCTACGGTGGTCCTAAA |
| Modified | ACCaGaTAcGAGGTgGACAAcATcACcCCTGTgCTgCTGGCccTGAGAACaTTcGCCCAGAGCAAgAGAGCcTTCCAgGCCATCAGAGGcGAgATcAAGCAcCTgTAtGGcGGcCCTAAg | |
| BFV | Native | GACCGTTATGCCGTCCACTCATCAGAACTAGTTTTATTGGCACTGACTACTCTGTCTAAGAACTTGAAGTCCTTCAGAAACATAAGAGGGAAACCAATACATCTCTACGGTGGTCCTAAA |
| Modified | GACaGaTAcGCCGTgCACTCtTCtGAgCTgGTgcTgcTGGCtCTGACcACaCTGagcAAGAACcTGAAGTCCTTCcGgAACATccGgGGcAAgCCcATcCATCTgTAtGGcGGaCCTAAg | |
| VEEV | Native | GCAGTAGAATCAAGGTATGAAACCGTAGGAACTTCCATCATAGTTATGGCCATGACTACTCTAGCTAGCAGTGTTAAATCATTCAGCTACCTGAGAGGGGCCCCTATAACTCTCTACGGC |
| Modified | GCAGTcGAgagcAGaTAcGAgACaGTgGGcACcagCATCATcGTgATGGCCATGACaACaCTgGCcAGCAGcGTgAAgTCcTTCAGCTACCTtAGAGGcGCCCCTATcACaCTgTACGGC | |
| EILV | Native | GCCGTATCATCAAGATACGAAGTCGACAACATACTGCCCGTTCTCTTAGCCCTTAGAACCTTTGCTTTATCTACGCGCAACTTCTCTGCCTTACGGGGAACACTTAAGACCCTCTACAAC |
| Modified | GCCGTgTCtagcAGATACGAgGTgGACAACATcCTGCCtGTgCTgcTgGCCCTgAGAACaTTTGCccTgagcACcaGaAACTTCagcGCCcTgaGaGGcACcCTgAAaACCCTgTACAAC |