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. 2021 May 6;17(8):2501–2516. doi: 10.1080/21645515.2021.1887692

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Overview of formulation experiments to assess the stability of Me and Ru (MeRu) viruses using a scaled-down lab model of Nanopatch^TM coating/drying process. Flowchart shows the preparation of MeRu samples in various formulations at targeted titer of 10^2.02 CCID₅₀/disc for each virus (1/10 human dose), loading of samples into 96-well plates with LCP discs, drying by nitrogen, incubation of dried samples under various storage conditions, reconstitution of samples, and then determination of viral titers and genomes by infectivity and genomic RT-qPCR assays. The bottom panel shows the data analysis procedure to determine % losses of viral titers and viral particles during formulation, drying and storage. The values of each sample were normalized to frozen bulk stored at −80°C (100%)