Figure 2.

Physicochemical analysis of VLP-PP formulations. (A) Change in z-average hydrodynamic diameter of PCPP-VLP and PCEP-VLP formulations versus time (D₀ – diameter at 0 h; PBS, pH 7.4, 4°C, 0.5 mg/mL PCPP or PCEP, 0.02 mg/mL VLPs); (B) endosomolytic activity of PCEP-VLP and PCEP-VLP formulations as assessed by their hemolytic activity at various pH (red blood cells, 0.025 mg/mL polymer concentration, 10 mM phosphate buffer, 0.9% sodium chloride)