Table 3.

Incidence rate of adverse events in different age groups of Zagreb and Essen regimen

	Zagreb					Essen
Age groups	≤10	11–20	21–50	51–60	>60	≤10	11–20	21–50	51–60	>60
N	23	15	41	21	20	17	24	40	17	22
Observations	92	60	164	84	79*	85	120	200	85	110
Local AEs
Induration	0 (0.00)	1 (1.67)	1 (0.61)	0 (0.00)	1 (1.27)	0 (0.00)	0 (0.00)	1 (0.50)	0 (0.00)	0 (0.00)
Erythema	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)
Swelling	0 (0.00)	0 (0.00)	1 (0.61)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	2 (1.00)	0 (0.00)	0 (0.00)
Pain	6 (6.52)	2 (3.33)	7 (4.27)	4 (4.76)	2 (2.53)	3 (3.53)	5 (4.17)	12 (6.00)	2 (2.35)	7 (6.36)
Itching	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)
Total	6 (6.52)	3 (5.00)	9 (5.49)	4 (4.76)	3 (3.80)	3 (3.53)	5 (4.17)	15 (7.50)	2 (2.35)	7 (6.36)
Systemic AEs
Fever	5 (5.43)	2 (3.33)	1 (0.61)	0 (0.00)	0 (0.00)	3 (3.53)	0 (0.00)	2 (1.00)	1 (1.18)	0 (0.00)
Allergy	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	1 (0.50)	0 (0.00)	0 (0.00)
Headache	0 (0.00)	0 (0.00)	0 (0.00)	1 (1.19)	1 (1.27)	0 (0.00)	0 (0.00)	0 (0.00)	1 (1.18)	0 (0.00)
Dysphoria	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)
Loss of appetite	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)
Nausea	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)	0 (0.00)
Total	5 (5.43)	2 (3.33)	1 (0.61)	1 (1.19)	1 (1.27)	3 (3.53)	0 (0.00)	3 (1.50)	2 (2.35)	0 (0.00)

*Note: One of the fourth dose was dropped out in Zagreb group.