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. Author manuscript; available in PMC: 2021 Sep 27.
Published in final edited form as: Trends Cell Biol. 2019 Mar 18;29(6):500–513. doi: 10.1016/j.tcb.2019.02.004

Figure 2. Regulation and Function of Inter-organelle Contact Sites.

Figure 2.

Inter-organelle membrane contact sites are sites of close apposition between the membranes of two distinct organelles which act as a domain for inter-organellar communication. Contact sites can form between many different organelles and are modulated by different types of proteins, including: (i) tethering proteins, (ii) functional proteins, and (iii) regulatory proteins, which can have overlapping roles and together help to maintain contact sites [50]. In addition, inter-organelle contacts have been linked to multiple functions, including: (i) metabolite transfer, (ii) regulation of organelle dynamics, and (iii) additional cellular processes allowing the maintenance of cellular homeostasis [45,52]. mtDNA, Mitochondrial DNA; ROS, reactive oxygen species.