Figure 4. Wnt inhibitor rescues glomerular fibrosis in diabetic control but not podocyte‐specific glucocorticoid receptor knockout (GR^PKO) mice.

A, Schematic diagram, showing the treatment protocol of Wnti (LGK974) and, (B) etomoxir (CPT1a inhibitor) in diabetic control and GR^PKO mice. C, Sirius red and Periodic acid‐Schiff staining in the glomeruli of diabetic mice was analyzed. Representative images are shown. Glomerular surface area was measured using ImageJ (n=5 to 6/group; scale bar 50 μm in each panel). D, Albumin‐to‐creatinine ratios from mice of each genotype subjected to either LGK974 or etomoxir (N=6 mice/group). Data are mean±SEM. *P<0.05; **P<0.01; ***P<0.001. One‐way ANOVA with Tukey's post hoc test was used.