Figure 7.

Histone hyperacetylation by Dexa treatment in the cultured cells is cancelled by a HAT inhibitor, L002, or a sirtuin activator, NMN. (A) Schematic representation of the study. (B) Dpp-4 gene expression on day 0.5 and (C) day 2 of the cultured cells treated with L002. (C) Dpp-4 gene expression of the cultured cells treated with NMN. (E) Dose-dependent effect of NMN on Dpp-4 gene expression in the Dexa-loaded cells. *P < 0.05, **P < 0.01 vs control. n.s., not significant vs without Dexa loading. ^#P < 0.05, ^##P < 0.01 vs without L002 or NMN. N = 8 per group. Dexa, dexamethasone; HAT, histone acetyltransferase; NMN, nicotinamide mononucleotide.