Table 2.

Associations between three independent SNPs in the FOXO pathway genes and BC in the DRIVE study

Genotype	Ncontrol/Ncase	Univariate analysis		Multivariate analysis*
		OR (95% CI)	P	OR (95% CI)	P
FBXO32 rsl0093411 A>G
AA	13782/15954	1.00		1.00
AG	8967/10850	1.05 (1.01–1.08)	0.016	1.05 (1.01–1.09)	0.010
GG	1500/1949	1.12 (1.05–1.21)	0.002	1.13 (1.05–1.21)	0.001
Trend test			0.0003		0.0002
AG+GG	10467/12799	1.06 (1.02–1.09)	0.002	1.06 (1.02–1.10)	0.001
FOXO6 rs61229336 OT
CC	10434/12758	1.00		1.00
CT	10956/12778	0.95 (0.92–0.99)	0.011	0.96 (0.92–0.99)	0.015
TT	2859/3217	0.92 (0.87–0.97)	0.004	0.92 (0.87–0.97)	0.004
Trend test			0.0009		0.001
CT+TT	13815/15995	0.95 (0.92–0.98)	0.002	0.95 (0.92–0.98)	0.003
FBXO32 rs62521280 C>T
CC	19400/22590	1.00		1.00
CT	4535/5801	1.10 (1.05–1.15)	<0.0001	1.10 (1.05–1.14)	<0.0001
TT	314/362	0.99 (0.85–1.15)	0.898	0.99 (0.85–1.16)	0.909
Trend test			0.0003		0.0005
CT+TT	4849/6163	1.09 (1.05–1.14)	<0.0001	1.09 (1.04–1.14)	0.0001
Number of combined risk genotypes †
0	6519/7378	1.00		1.00
1	10789/12517	1.03 (0.98–1.07)	0.249	1.02 (0.98–1.07)	0.270
2	5862/7371	1.11 (1.06–1.17)	<0.0001	1.11 (1.06–1.16)	<0.0001
3	1079/1487	1.22 (1.12–1.33)	<0.0001	1.22 (1.11–1.33)	<0.0001
Trend test			<0.0001		<0.0001
0–1	17308/19895	1.00		1.00
2–3	6941/8858	1.11 (1.07–1.15)	<0.0001	1.11 (1.07–1.15)	<0.0001

Abbreviations: BC: breast cancer; CI: confidence interval; DRIVE: Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; FBXO32, F-box protein 32; FOXO: Forkhead box O; FOXO6, Forkhead box O6; OR: odd ratio; SNP: single nucleotide polymorphism.

^*Adjusted for age, PC1, PC3, PC4, PC5, PC6, PC8, PC10, PC11, PC14 and PC16.

^†Risk genotypes were rs10093411 AG+GG, rs61229336 CC and rs62521280 CT+TT.