Table 3.

Stratified analysis for associations between risk genotypes and BC in the DRIVE study

Characteristics	NRG 0–1		NRG 2–3		Univariate analysis		Multivariate analysis*		P inter †
	Control	Case	Control	Case	OR (95% CI)	P	OR (95% CI)	P
Age
≤60	9090	8544	3635	3882	1.14 (1.08–1.20)	<0.0001	1.13 (1.07–1.19)	<0.0001	0.348
>60	8218	11351	3306	4976	1.09 (1.03–1.15)	0.001	1.09 (1.03–1.15)	0.001
ER+ vs. control
≤60	9090	5274	3635	2329	1.10 (1.04–1.18)	0.002	1.12 (1.05–1.19)	0.0006	0.518
>60	8218	8022	3306	3477	1.08 (1.02–1.14)	0.010	1.08 (1.02–1.15)	0.006
ER− vs. control
≤60	9090	1281	3635	636	1.24 (1.12–1.38)	<0.0001	1.17 (1.05–1.30)	0.004	0.966
>60	8218	1215	3306	574	1.17 (1.06–1.31)	0.003	1.16 (1.04–1.30)	0.006
Invasiveness vs. control
≤60	9090	7647	3635	3438	1.12 (1.06–1.19)	<0.0001	1.12 (1.06–1.19)	<0.0001	0.356
>60	8218	10349	3306	4502	1.08 (1.02–1.14)	0.004	1.08 (1.03–1.14)	0.003
In-situ vs. control
≤60	9090	744	3635	348	1.17 (1.02–1.34)	0.021	1.17 (1.02–1.34)	0.022	0.538
>60	8218	832	3306	370	1.11 (0.97–1.26)	0.128	1.10 (0.97–1.25)	0.155

^*Adjusted for PC1, PC3, PC4, PC5, PC6, PC8, PC10, PC11, PC14 and PC16.

^†P_inter: P value for interaction analysis between age and NRG.

Abbreviations: BC: breast cancer; CI: confidence interval; DRIVE: Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; ER: estrogen receptor; NRG: number of risk genotypes; OR: odds ratio.