Table 2.
Characteristics of zonula occludens (ZO) proteins and junctional adhesion molecules (JAM) and their changes in intestinal diseases.
| Tight junction protein | Size (kDa) | Interactions | Role in disease |
|---|---|---|---|
| ZO-1 | ~220 kDa | Claudin, JAM-A, occludin, F-actin, ZO-2,-3, cingulin | ↓ Crohn's disease (119) IBS-D (120), IBS-A (121) Celiac disease (122) |
| ZO-2 | ~160 kDa | Claudin, occludin, F-actin, ZO-1,-3, cingulin | ↓ IBS-D (120) |
| ZO-3 | ~130 kDa | Claudin, occludin, ZO-1, cingulin | ↓ IBS-D (120) |
| JAM-A | ~40 kDa | Occludin, JAM-A, ZO-1, cingulin | ↓ In IBD (75, 83, 123) IBS-D and IBS-A (124) |
| JAM-B | ~40 kDa | JAM-C, ZO-1 | - |
| JAM-C | ~40 kDa | JAM-B, JAM-C, ZO-1 | - |