TABLE 1.

Effects of treatment interventions on perimenopausal depression^a

Treatment	Treatment class	Effect
Desvenlafaxine	SNRI	Decreased depressive symptoms as monotherapy (46, 48)
Cognitive-behavioral therapy	Psychotherapy	Decreased depressive symptoms as monotherapy (46)
Escitalopram	SSRI	Decreased depressive symptoms as monotherapy (46, 49)
Transdermal estradiol (with and/or without progesterone, dependent on intact uterus)	Hormone therapy	Decreased depressive symptoms as monotherapy or adjunctive treatment (46, 49, 50) Prevention of depressive symptoms as monotherapy (51)
Tibolone	STEAR	Decreased depressive symptoms as adjunctive treatment (52)
Vortioxetine	Serotonin modulator	Decreased depressive symptoms as monotherapy (53)

^aSNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; STEAR, selective tissue estrogenic activity regulator.