Table 2. Univariate and multivariable cox regression analysis on OS.

	Univariate Cox					Multivariate Cox
Variables	HR	95% CI	P-value		HR	95% CI	P-value
CIP4 (high vs. low)	0.522	0.293–0.830	0.027		0.61	0.326–0.912	0.012
Age(>60 vs.≤60)	0.806	0.454–1.429	0.46		0.738	0.399–1.366	0.334
Gender(male vs.female)	0.297	0.151–0.586	<0.001		0.375	0.179–0.784	0.009
AJCC stage(III-IV vs.I-II)	0.782	0.366–1.672	0.057		0.568	0.174–1.861	0.351
Tumor stage (3–4 vs.1-2)	1.451	1.363–1.656	0.044		1.547	1.497–4.771	0.045
Lymph node status(2–3 vs.0-1)	1.894	1.060–3.383	0.031		2.823	0.887–8.990	0.079
Metastasis(1 vs.0)	4.86	1.670–14.146	0.004		2.031	1.059–3.897	0.033
Race(White vs.No white)	1.421	0.748–2.699	0.284		1.373	0.689–2.734	0.367
Alcohol history(No vs.Yes)	1.497	0.846–2.650	0.166		1.528	0.794–2.940	0.204
Smokinghistory(No vs.Yes)	1.061	0.588–1.912	0.166		1.047	0.566–1.938	0.884

Abbreviations: CI, confidence interval; HR, hazard ratio; OS, overall survival.