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. 2021 May 9;80(9):890–892. doi: 10.1093/jnen/nlab034

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© 2021 American Association of Neuropathologists, Inc. All rights reserved.

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FIGURE 2. — FET pathology. (A) Grossly, the hippocampus appears severely atrophic. (B) Low-power view shows severe hippocampal sclerosis with pallor and rarefaction in CA1. (C) Cytoplasmic rounded inclusions are identified in dentate gyrus granular neurons with FUS immunohistochemistry (IHC). (D) TAF15 IHC highlights cytoplasmic and intranuclear inclusions in dentate granular neurons. (E) Sections of the basal ganglia show severe neuron loss and gliosis. (F) Rare FUS-positive curvi-linear intranuclear inclusions are seen in the putamen. (G) TAF15 IHC highlights both cytoplasmic and curvilinear intranuclear inclusions in basis pontis nuclei. (H) Rare cortical neurons contain TAF15-immunoreactive cytoplasmic inclusions.