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. 2021 May 27;38(10):4588–4602. doi: 10.1093/molbev/msab162

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Model fits to joint allele frequency spectra (AFS) using nonsynonymous data. (A) Joint AFS for the human nonsynonymous data, the best fit model with DFE correlation w = 0.995, and the residuals between model and data. (B) Joint AFS for the Drosophila melanogaster nonsynonymous data and the best fit model with DFE correlation w = 0.967. (C) Joint AFS for the wild tomato nonsynonymous data and the best fit model with DFE correlation w = 0.905. In all three cases, residuals are small for almost all entries in the AFS, so to increase contrast the color range has been restricted to ±3. See supplementary figure S8, Supplementary Material online for plots showing the full residual range.