Fig. 6.

Two possible evolutionary pathways of CPF. The first common ancestor of CPF might be (A) a 6-4 photolyase with an iron–sulfur cluster like a FeS-BCP, or (B) a CPD photolyase with a single α-helical domain and an iron–sulfur cluster like a SPL. Proposed major evolutionary events are indicated by colored dots. SPL, short photolyase-likes; CPD I, class I CPD photolyases; CPD III, class III CPD photolyases; pCry, plant cryptochromes; DASH, DASH proteins; Eu64, eukaryotic 6-4 photolyases; aCry, animal cryptochromes; DASH-like, DASH-like proteins; CPD II, class II CPD photolyases; FeS-BCP, FeS-BCP proteins.