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. 2021 Sep 28;27(36):6079–6092. doi: 10.3748/wjg.v27.i36.6079

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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miR-588 can target cylindromatosis in gastric cancer cells. A: The binding site of miR-588 and cylindromatosis (CYLD) was predicted in TargetScan database; B-D: After cisplatin (DDP)-resistant SGC7901 cells were treated with miR-588 mimic, the luciferase activity of CYLD was measured by luciferase reporter assays (B); the expression of CYLD was determined by qPCR (C); and the expression of CYLD was measured by Western blot analysis (D). Data shown are the mean ± SD. ^bP < 0.01. CYLD: Cylindromatosis.