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. 2021 Sep 17;47:102133. doi: 10.1016/j.redox.2021.102133

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© 2021 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — H₂O₂ production of human PMN activated by PMA and inhibited by zinc.

A) In seven independent experiments H₂O₂ release was measured over 120 min. Zinc concentrations from 1 μM to 3 mM inhibit H₂O₂ release. Data is displayed as Mean ± SD. Overall release of H₂O₂ is seen at 120 min. Maximal rate of production is determined at the steepest slope of H₂O₂ release over time. Data was normalized to a single cell (n = 7). B) Inhibition response curve giving an IC₅₀ = 21 μM Zn²⁺. C) Dixon Plot fitted with a Michaelis-Menten-Equation showing an apparent K_M =799 μM Zn²⁺.