Table 1.

Test datasets used and the number of deleterious and benign variants for each dataset used for evaluation.

References	Dataset	Description	ND	NB
Grimm et al.1	HumVar	Disease-causing mutations from UniProtKB and common single nucleotide polymorphisms with major allele frequency > 1%1	1230	1230
	Total		1230	1230
Mahmood et al.2	UniFun	Deleterious and benign variants in UniProt which are derived from functional assays2	25	25
	BRCA1-DMS	Deleterious and benign variants derived from deep mutational scanning experiment measuring homology-directed DNA repair and tumor suppression activity2	41	41
	TP53-TA	Deleterious and benign variants derived from transactivation assay2	413	413
	Total		479	479
Total			1709	1709

ND stands for the number of deleterious variants, and NB stands for the number of benign variants.