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. 2021 Sep 27;11:19116. doi: 10.1038/s41598-021-98771-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TMZ promotes PA-attenuated mitochondrial quality control (MQC) and functions in muscle cells. (a, b) P-AMPK, PGC-1α, LC3II/LC3I, BNIP3, MFN1, and DRP1 protein expression were determined by Western blot. (c) Laser scanning confocal microscope by using LysoTracker and mitoTacker. The colocalizations of lysoTracker and mitoTracker represented mitolysosomes (scale bar = 25 μm). (d) Transmission electron microscope imaging. The damaged mitochondria were indicated in TEM images (red arrow). (e, f) OCR: cellular oxygen consumption. m: mitochondria. (g, h) CS protein expression was determined by Western blot. *, ** represented p < 0.05, p < 0.01 in comparison with the Con group, respectively; ^#, ^## represented p < 0.05, p < 0.01 in comparison with the PA group, respectively.