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. 2021 Sep 27;11:19116. doi: 10.1038/s41598-021-98771-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Diagram of animal experiments. After a 1-week adaptive feeding, mice were randomly divided into four groups: normal diet (ND), high-fat diet (HFD), HFD + Trimetazidine (HFD + TMZ), and HFD + exercise (HFD + EX). 8 weeks later, mice in each group were randomly divided into two subgroups: normal control subgroup and exhaustive exercise (EE) subgroup, the subsequent experiments were performed as the diagram shows.